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目的:观察救肾灌肠方治疗糖尿病肾病的临床疗效。方法:将合格受试对象200例随机分为治疗组102例和对照组98例。两组均采用西药常规降糖降压治疗,治疗组加用救肾灌肠方灌肠,1次/d,30d为1疗程,1个疗程后统计疗效。治疗前后观察糖代谢、血压、血清肌酐、尿素氮、24h尿蛋白、尿白蛋白排泄率等指标。结果:两组近期总有效率治疗组优于对照组(P<0.01);两组治疗后尿素氮、血清肌酐、尿白蛋白排泄率、空腹血糖、餐后2h血糖、糖化血红蛋白较治疗前均下降(P<0.01),治疗后以上各指标与对照组比较,差异均有统计学意义(P<0.05)。24h尿蛋白定量治疗前、后与对照组比较,差异均无统计学意义(P>0.05)。结论:“救肾灌肠方”灌肠是一种有效延缓糖尿病肾病肾功能恶化的治疗方法,疗效肯定,方法简单,副反应少。
Objective: To observe the clinical efficacy of Xijian enema in the treatment of diabetic nephropathy. Methods: 200 eligible subjects were randomly divided into treatment group 102 cases and control group 98 cases. The two groups were treated with conventional blood sugar lowering antihypertensive treatment, the treatment group with salvage enema enema enema, 1 / d, 30d for a course of treatment, a course of treatment after statistical effect. Before and after treatment of glucose metabolism, blood pressure, serum creatinine, urea nitrogen, 24h urinary protein, urinary albumin excretion rate and other indicators. Results: The total effective rate of the two groups was better than that of the control group (P <0.01). After treatment, the blood urea nitrogen, serum creatinine, urinary albumin excretion rate, fasting blood glucose, 2h postprandial blood glucose and glycosylated hemoglobin (P <0.01). After treatment, the above indexes were significantly different from the control group (P <0.05). 24h urine protein before and after treatment, compared with the control group, the difference was not statistically significant (P> 0.05). Conclusion: “Saline - saving enema enema” is an effective treatment of diabetic nephropathy to delay the deterioration of renal function therapy, positive effect, the method is simple, less side effects.