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目的了解围产期孕妇及新生儿B群链球菌(GBS)的感染类型及耐药状况,为临床提供防治依据。方法收集本院2014年7月-2016年6月感染GBS的围产期孕妇和新生儿的菌株和临床资料,回顾性研究GBS引起的感染类型并进行耐药性分析。结果共收集发生GBS感染的患者122例,其中围产期孕妇111例,新生儿8例,先兆流产患者3例。111例感染GBS的孕妇胎膜早破发生率为76%。113例新生儿(母亲感染GBS)中有45例入住新生儿科,入院率达40%。122株GBS药敏结果显示,对青霉素、氨苄西林、万古霉素和利奈唑胺的敏感率均为100.0%,耐药率最高的为克林霉素,高达96.0%。结论 GBS是围产期孕产妇和新生儿感染的重要条件致病菌,青霉素可作为治疗的首选药。临床应重视围产期孕妇和新生儿的GBS筛查,做到早发现、早预防、早治疗。
Objective To understand the types and drug resistance of perinatal pregnant women and newborns with group B streptococcus (GBS), so as to provide basis for prevention and treatment. Methods The strains and clinical data of perinatal pregnant women and newborns infected with GBS from July 2014 to June 2016 in our hospital were collected. The types of infections caused by GBS were retrospectively studied and analyzed for drug resistance. Results A total of 122 patients with GBS infection were collected, including 111 perinatal pregnant women, 8 newborns and 3 threatened abortion. The incidence of premature rupture of membranes in 111 cases infected with GBS was 76%. Of the 113 newborns (mothers infected with GBS), 45 were admitted to the Neonatology department with a 40% admission rate. The results of 122 strains of GBS showed that the sensitivity rates to penicillin, ampicillin, vancomycin and linezolid were all 100.0%, and the highest rates of resistance were clindamycin, up to 96.0%. Conclusion GBS is an important pathogenic bacterium in perinatal maternal and newborn infections. Penicillin can be used as the first choice of treatment. Clinical should pay attention to perinatal pregnant women and neonatal GBS screening, early detection, early prevention, early treatment.