论文部分内容阅读
目的探讨消风Ⅱ号胶囊对大鼠佐剂性关节炎(AA)的作用。方法应用弗氏完全佐剂诱导大鼠实验性关节炎模型,于第15d开始灌胃给予消风Ⅱ号胶囊,连续给药14d。测量大鼠体重、胸腺指数、脾脏指数、足肿胀度,HE染色观察大鼠踝关节病理组织学变化。结果消风Ⅱ号胶囊能缓解AA病情,使足肿胀度下降,体重及脏器指数改善,关节水肿减轻,淋巴细胞浸润明显减少,滑膜增生受抑制。结论消风Ⅱ号胶囊对AA大鼠有治疗作用。
Objective To investigate the effect of Xiaofeng II capsule on adjuvant arthritis (AA) in rats. Methods Freund’s complete adjuvant was used to induce experimental arthritis in rats. On the 15th day, Xiaofeng II capsules were given by intragastric administration for 14 days. The body weight, thymus index, spleen index, and swelling degree of the feet were measured. HE staining was used to observe the pathological changes of the ankle joints in rats. Results Xiaofeng II capsule can relieve AA condition, reduce foot swelling, improve body weight and organ index, reduce joint edema, decrease lymphocyte infiltration, and inhibit synovial hyperplasia. Conclusion Xiaofeng II capsule has therapeutic effects on AA rats.