论文部分内容阅读
目的观察酸帕洛诺司琼预防化疗所致恶心和呕吐的疗效和安全性。方法选取2012年1月至2013年12月间收治的100例恶性肿瘤患者,采用随机数字表法分成试验组和对照组,每组52例。试验组患者应用盐酸帕洛诺司琼,对照组患者应用盐酸托烷司琼。对化疗当日及化疗后1~7 d的恶心、呕吐程度、控制效果及不良反应进行评价。结果试验组和对照组患者用药后急性恶心控制率分别为78.0%和76.0%,急性呕吐控制率分别为80.0%和74.0%,差异无统计学意义(P>0.05)。试验组和对照组患者的延迟性呕吐控制率分别为70.0%和48.0%,差异有统计学意义(P<0.05)。结论盐酸帕洛诺司琼注射液对防治化疗引起的延迟性呕吐的疗效和安全性较好。
Objective To observe the efficacy and safety of acid palonosetron in preventing chemotherapy-induced nausea and vomiting. Methods A total of 100 patients with malignant tumors who were admitted between January 2012 and December 2013 were divided into experimental group and control group by random number table, with 52 patients in each group. Palonosetron hydrochloride was used in the test group and tropisetron hydrochloride was used in the control group. On the day of chemotherapy and 1 ~ 7 days after chemotherapy nausea, vomiting, control effects and adverse reactions were evaluated. Results The control rates of acute nausea and nausea were 78.0% and 76.0% in the test group and the control group, respectively. The rates of acute emesis were 80.0% and 74.0%, respectively, with no significant difference (P> 0.05). The control rates of delayed emesis in trial group and control group were 70.0% and 48.0%, respectively, with statistical significance (P <0.05). Conclusion Palonosetron hydrochloride injection is effective and safe in preventing and treating delayed vomiting caused by chemotherapy.