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目的分析2型糖尿病(T2DM)患者发生颈动脉粥样硬化(CAS)的影响因素。方法依据颈动脉超声有无CAS,188例T2DM患者分为CAS组(95例)和非CAS组(93例),比较两组的相关指标,分析发生CAS的影响因素。结果两组间糖尿病病程、高血压病程、吸烟和高血压比例、踝肱指数、颈动脉内膜中层厚度和LDL-C水平差异均有统计学意义(P<0.05)。Logistic回归分析显示,高龄、糖尿病病程和吸烟史长、低踝肱指数是T2DM患者发生CAS的危险因素(P<0.05或P<0.01)。结论踝肱指数、年龄、糖尿病病程、吸烟史是T2DM患者发生CAS的独立影响因素,T2DM患者应定期检测踝肱指数,以便早期评估CAS的发生。
Objective To analyze the influencing factors of carotid atherosclerosis (CAS) in type 2 diabetes mellitus (T2DM). Methods According to the presence or absence of CAS in 188 cases of T2DM, 188 patients with T2DM were divided into CAS group (95 cases) and non-CAS group (93 cases). The relevant indexes of the two groups were compared to analyze the influencing factors of CAS. Results The duration of diabetes, duration of hypertension, smoking and hypertension, ankle brachial index, carotid artery intima-media thickness and LDL-C level were significantly different between the two groups (P <0.05). Logistic regression analysis showed that senior citizens, long duration of diabetes, long history of smoking and low ankle brachial index were the risk factors of CAS in T2DM patients (P <0.05 or P <0.01). Conclusions Ankle brachial index, age, duration of diabetes and smoking history are independent risk factors of CAS in T2DM patients. T2MI patients should be monitored regularly for ankle-brachial index in order to evaluate the occurrence of CAS early.