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目的：研究急性心肌梗塞（ＡＭＩ）患者血浆内皮素（ＥＴ）的变化。方法：ＡＭＩ患者随机分溶栓（１７例）与非溶栓（１４例）两组。溶栓组分为溶栓成功组９例（早期再灌），溶栓未成功组８例（非早期再灌）。测外周血浆ＥＴ值，并于入院后３周左右行彩色多普勒扫描。结果：ＡＭＩ患者入院初血浆ＥＴ浓度明显高于正常组，早期再灌较非再灌高峰更高及高峰前移且持续时间短，各组ＥＴ峰值与彩色多普勒测得左室射血分数（ＬＶＥＦ）无明显相关，心功能（Ｋｉｌｌｉｐ）分级越高其血浆ＥＴ峰值越高。结论：ＥＴ在ＡＭＩ的冠脉再通的发生和发展中起一定的作用。
Objective: To study the changes of plasma endothelin (ET) in patients with acute myocardial infarction (AMI). Methods: AMI patients were randomly divided into two groups: thrombolysis (17 cases) and non thrombolysis (14 cases). The thrombolytic component consisted of 9 patients with successful thrombolysis (early reperfusion) and 8 patients with unsuccessful thrombolysis (non-early reperfusion). Measurement of peripheral plasma ET values, and about 3 weeks after admission line color Doppler scan. Results: At the beginning of admission, the plasma ET concentration in patients with AMI was significantly higher than that in the normal group. The early reperfusion was higher than the non-reperfusion peak and the peak time was shortened. The peak values of ET and color Doppler echocardiography (LVEF). The higher the Killip grade, the higher the plasma ET level. Conclusion: ET plays a certain role in the occurrence and development of coronary recanalization in AMI.