论文部分内容阅读
目的观察冠心病患者血浆中髓过氧化酶(MPO)在经皮冠状动脉介入治疗术(PCI)前后的变化,探讨MPO与冠心病的临床关系。方法将78例行PCI术患者分为急性冠状动脉综合征组(ACS,51例)和稳定性心绞痛组(SAP,27例),分别在手术前后取血测MPO、C反应蛋白(CRP),分析两者在PCI术前后的变化及联系,MPO与冠状动脉病变的相关性。结果手术前ACS组血浆MPO、CRP均明显高于SAP组(P<0.05);ACS组MPO水平与CRP明显相关(P<0.05),两组MPO水平与冠状动脉病变的Gensini评分均无相关性;手术后两组CRP均升高明显(P<0.05),而MPO的变化不明显(P>0.05)。结论血浆MPO与冠状动脉病变、介入术中斑块损伤的相关性不明显,可作为预测、评估ACS的有效指标。
Objective To observe the changes of plasma myeloperoxidase (MPO) in patients with coronary heart disease before and after percutaneous coronary intervention (PCI) and to explore the clinical relationship between MPO and coronary heart disease. Methods A total of 78 patients undergoing PCI were divided into acute coronary syndrome group (ACS, n = 51) and stable angina pectoris group (SAP, 27 patients). Blood samples were collected before and after the operation for detecting the levels of MPO, C-reactive protein The changes and their relationship between the two before and after PCI were analyzed, and the correlation between MPO and coronary artery disease was analyzed. Results The plasma levels of MPO and CRP in preoperative ACS group were significantly higher than those in SAP group (P <0.05). The level of MPO in ACS group was significantly correlated with CRP (P <0.05). There was no correlation between MPO level and Gensini score in coronary artery disease The levels of CRP in both groups increased significantly after operation (P <0.05), while the changes of MPO did not change significantly (P> 0.05). Conclusion There is no obvious correlation between plasma MPO and coronary artery lesion and plaque injury during intervention. It can be used as an effective index to predict and evaluate ACS.