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目的探讨甲氨蝶呤(MTX)联合米非司酮治疗非破裂输卵管妊娠的效果。方法随机选取32例非破裂型输卵管妊娠患者采用米非司酮300 mg一次顿服,MTX20 mg静脉滴注5 d。另选32例单用MTX的患者设为对照组。结果MTX联合米非司酮治疗的成功率为87.5%,明显高于对照组。观察治疗期间病情变化,发现疗效与血β-hCG高低及有无心管搏动有关。结论MTX联合米非司酮治疗非破裂型输卵管妊娠安全有效,适用于生命体征平稳、无剧烈腹痛、无心管搏动及血β-hCG<2000 IU/l的非破裂型输卵管妊娠。
Objective To investigate the effect of methotrexate (MTX) combined with mifepristone in the treatment of non-ruptured tubal pregnancy. Methods 32 cases of non-ruptured tubal pregnancy randomly selected mifepristone 300 mg once daily dose, MTX20 mg intravenous infusion of 5 d. Another 32 cases of patients with MTX alone as the control group. Results MTX combined with mifepristone treatment success rate was 87.5%, significantly higher than the control group. Observed during the treatment of changes in the condition and found that the efficacy of blood β-hCG levels and whether or not cardiac tube beating related. Conclusion MTX combined with mifepristone in the treatment of non-ruptured tubal pregnancy is safe and effective. It is suitable for non-ruptured tubal pregnancy with stable vital signs, no severe abdominal pain, no cardiac tube beating and blood β-hCG <2000 IU / l.