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目的 观察抗胆碱能受体阻滞剂在儿童哮喘治疗中的作用及肺功能呼气峰流速 (PEFR)的变化。方法 用溴化异丙托品联合沙丁胺醇雾化吸入治疗儿童支气管哮喘急性发作 (n =1 1 ) ,而对照组单用沙丁胺醇吸入治疗 (n =9) ,并监测PEFR的变化。结果 治疗组加用溴化异丙托品后 40 ,6 0 ,80min的PEFR值 (占预计值的百分比 )分别为 6 8.8± 5 .6 % ;72 .0± 3.4% ,71 .1± 3.7% ,与单用沙丁胺醇的PEFT值 6 0 .6± 5 .7% ,6 0 .8± 6 .3% ,5 9.1± 6 .7%比较有显著性差异 (均P <0 .0 1 )。结论 溴化异丙托品与沙丁胺醇联合应用 ,其肺功能改善程度较单用沙丁胺醇更明显 ,扩张支气管作用时间更长 ,副作用少。
Objective To observe the role of anticholinergic blockers in the treatment of childhood asthma and the changes of pulmonary expiratory peak flow velocity (PEFR). Methods Acute episode of childhood bronchial asthma was treated with ipratropium bromide plus salbutamol inhalation (n = 11), while the control group was treated with salbutamol alone (n = 9) and the changes of PEFR were monitored. Results The PEFR values at 40, 60 and 80 min after treatment with ipratropium bromide in the treatment group were 6 8.8 ± 5 .6%, 72 .0 ± 3.4% and 71.1 ± 3.7, respectively %, Respectively. There was significant difference (P <0.01) with the PEFT value of salbutamol alone.60.6 ± 5.7%, 60.8 ± 6.3% and 5 9.1 ± 6.7% . Conclusions The combination of ipratropium bromide and albuterol can improve pulmonary function more effectively than albuterol alone, extend bronchial action longer and have fewer side effects.