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目的总结小儿甲型肝炎的临床特征和临床转归。方法对我院2011年5月至2011年8月收治的58例甲型肝炎患儿的临床资料进行回顾性分析。观察治疗前后患者临床症状、肝功能指标和B超检查结果的变化。结果 58例小儿经促肝细胞生长素联合门冬氨酸钾镁注射液治疗10 d后,30例患儿血清丙氨酸氨基转移酶由治疗前的(909.38±938.76)U/L降为治疗后的(93.55±72.83)U/L;门冬氨酸氨基转移酶由治疗前的(637.09±687.93)U/L降为治疗后的(46.29±23.10)U/L;治疗3 w后28例患者胆红素由治疗前的(55.81±38.83)μmol/L降为治疗后的(21.94±22.78)μmol/L。3 m后全部患者血清抗-HAV IgM均呈阴性。全部患者治愈出院。结论小儿甲型肝炎预后良好,重在预防。
Objective To summarize the clinical characteristics and clinical outcome of pediatric hepatitis A. Methods The clinical data of 58 children with hepatitis A admitted to our hospital from May 2011 to August 2011 were analyzed retrospectively. The changes of clinical symptoms, liver function indexes and B-ultrasound findings before and after treatment were observed. Results After treatment of 58 patients with hepatocyte growth-promoting hormone combined with potassium-magnesium aspartate injection for 10 days, serum alanine aminotransferase in 30 children was reduced from 909.38 ± 938.76 U / L before treatment to treatment (93.55 ± 72.83) U / L, and aspartate aminotransferase decreased from (637.09 ± 687.93) U / L before treatment to (46.29 ± 23.10) U / L after treatment Patients’ bilirubin decreased from (55.81 ± 38.83) μmol / L before treatment to (21.94 ± 22.78) μmol / L after treatment. All patients’ serum anti-HAV IgM was negative after 3 m. All patients were cured and discharged. Conclusion The prognosis of children with hepatitis A is good, focusing on prevention.