论文部分内容阅读
目的分析铜绿假单胞菌的分布和耐药性变化,为临床防治铜绿假单胞菌感染提供依据。方法收集成都大学附属医院2014-2016年所分离的铜绿假单胞菌,采用VITEK 2-Compact全自动细菌鉴定系统进行鉴定和药敏试验,采用WHONET 5.6软件对数据进行分析。结果3年间共分离出1 945株铜绿假单胞菌,多重耐药铜绿假单胞菌分离率为34.2%(666/1945)。标本来源以呼吸道为主,占82.2%(1598/1945)。科室分布以呼吸内科最多,ICU其次。铜绿假单胞菌对头孢曲松和头孢噻肟的耐药率最高,均>57.0%;对阿米卡星耐药率最低,为2.0%。3年来铜绿假单胞菌对17种抗生素的耐药率呈整体上升的趋势。结论铜绿假单胞菌对头孢曲松、头孢噻肟、亚胺培南耐药率较高,对阿米卡星耐药率较低。铜绿假单胞菌的耐药率呈整体上升的趋势,应重视细菌耐药性的监测,以延缓耐药性产生、促进临床合理用药。
Objective To analyze the distribution and drug resistance changes of Pseudomonas aeruginosa and provide basis for clinical prevention and treatment of Pseudomonas aeruginosa infection. Methods Pseudomonas aeruginosa isolated from Affiliated Hospital of Chengdu University from 2014 to 2016 was collected and identified by VITEK 2-Compact automatic bacterial identification system. The data were analyzed by WHONET 5.6 software. Results A total of 1 945 strains of Pseudomonas aeruginosa were isolated in 3 years. The isolation rate of multidrug-resistant Pseudomonas aeruginosa was 34.2% (666/1945). The main source of the respiratory tract specimens, accounting for 82.2% (1598/1945). Department of respiratory medicine distribution to most, followed by ICU. The resistance rates of Pseudomonas aeruginosa to ceftriaxone and cefotaxime were the highest, both> 57.0%. The resistance rates to amikacin were the lowest, 2.0%. In the past three years, the resistance rate of Pseudomonas aeruginosa to 17 kinds of antibiotics showed an overall upward trend. Conclusion Pseudomonas aeruginosa has a higher resistance rate to ceftriaxone, cefotaxime and imipenem, and a lower resistance to amikacin. The resistance rate of Pseudomonas aeruginosa showed an overall upward trend, should pay attention to the monitoring of bacterial resistance, in order to delay the emergence of drug resistance, and promote the rational use of clinical medicine.