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目的探讨急性低压缺氧对飞行人员血浆乳酸 (LA)及乳酸脱氢酶 (LDH)含量的影响。方法用比色法测定了 1 6名健康男性歼击机飞行人员清晨 (6∶0 0a .m .)、急性中度低压缺氧 2 0min后即刻 (1 0∶0 0a .m .)及下降至地面 6h后 (4∶0 0 p .m .)的血浆LA及LDH含量 ,并以 1 6名健康男性地面人员相应时间的测定作对照。结果实验组急性中度低压缺氧 2 0min后即刻 ,血浆LA水平明显高于实验前及实验后 6h ,也高于同一时间对照组 (P <0 .0 1 ) ,实验后 6h时血浆LA含量下降 ,与实验前及同一时间对照组相比较无显著性差异 (P >0 .0 5)。实验组急性中度低压缺氧 2 0min后即刻 ,血浆乳酸脱氢酶含量与实验前及实验后 6h以及同一时间对照组相比均无显著性差异 (P >0 .0 5)。结论急性中度低压缺氧能使飞行人员血浆乳酸水平升高 ,出舱后 6h内恢复正常 ,而LDH无明显变化。
Objective To investigate the effects of acute hypobaric hypoxia on plasma lactic acid (LA) and lactate dehydrogenase (LDH) levels in pilots. Methods The colorimetric method was used to detect the abnormality of 16 healthy male fighter pilots in early morning (6:00 a.m.), acute moderate hypobaric hypoxia (0:00 a.m.) After 6h (4:00 p .m.) Of plasma LA and LDH levels, and 16 healthy men on the ground corresponding time as a control. Results After acute hypobaric hypoxia for 20 minutes, the level of plasma LA in experimental group was significantly higher than that before experiment and 6 hours after experiment, and also higher than that of control group (P <0.01) at 6 hours after experiment. There was no significant difference between the control group and the control group before and at the same time (P> 0.05). There was no significant difference in plasma lactate dehydrogenase level between the experimental group and the control group at 6 h and 6 h after the experiment (P> 0.05). Conclusion Acute hypobaric hypoxia can increase the level of plasma lactate in pilots, return to normal within 6 hours after exiting, and no significant change in LDH.