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目的探讨鼻咽癌常规分割放疗中等效生物剂量及总疗程时间对局控和生存的影响。材料与方法１５７例病理确认并进行ＣＴ检查的鼻咽癌于１９９２年３月至１９９４年４月完成常规分割根治性放疗，每次鼻咽中心剂量１．７１～１．９９Ｇｙ（中位每天每次１．８５Ｇｙ），总剂量６２．３～８４．０３Ｇｙ，照射３３～４５次／４８～７９天（中位７２．３Ｇｙ，３９次／５７天）。用总疗程时间及潜在倍增时间Ｔｐｏｔ（Ｔｐｏｔ＝４．０天）校正等效生物剂量，在分析总疗程时间的作用时，选择校正前等效生物剂量（Ｂｉｏｌｏｇｉｃａｌｅｆｅｃｔｉｖｅｄｏｓｅ，ＢＥＤ）在７９～９１Ｇｙ内的１２８例进行分析。应用Ｃｏｘ模型分析年龄、性别、Ｔ分期、Ｎ分期、等效生物剂量及总疗程时间对局控和生存率的影响。结果本组病例的３年生存率为６５．８％，３年无瘤生存率５６．６％，３年局控率７４．８％。影响生存和局控率的因素为Ｔ分期、等效生物剂量和总疗程时间。等效生物剂量＜４９Ｇｙ与≥４９Ｇｙ的３年生存率和局控率分别为３４．３％、５４．４％（Ｐ＝０．００１）和６９．７％、７７．１％（Ｐ＝０．００９）。校正前ＢＥＤ在７９～９１Ｇｙ范围内的１２８例患者中总疗程时间≤５６天与＞５６天的３?
Objective To investigate the effects of the equivalent biological dose and the total duration of treatment on the control and survival of nasopharyngeal carcinoma under conventional fractionated radiotherapy. Materials and Methods 157 cases of pathologically confirmed and CT examination of nasopharyngeal carcinoma in March 1992 to April 1994 to complete the conventional split radical radiotherapy, each nasopharyngeal center dose of 1.71 ~ 1.99Gy (median daily Times of 1.85Gy). The total dose was 62.3-84.03Gy and 33-45 times / 48-79 days (median 72.3Gy, 39 times / 57 days). The equivalent biological dose was corrected with the total duration of treatment and the potential doubling time Tpot (Tpot = 4.0 days). During the analysis of the effect of the total duration of treatment, the bioequivalent bioassay (BED) was selected to be 79 to 91 Gy 128 cases were analyzed. Cox model was used to analyze the effects of age, sex, T stage, N stage, equivalent biological dose and total duration of treatment on the control and survival rate. Results The 3-year survival rate was 65.8%, the 3-year disease-free survival rate was 56.6%, and the 3-year local control rate was 74.8%. The factors influencing the survival and the control rate were T staging, equivalent biological dose and the total duration of treatment. The 3-year survival rates and control rates of equivalent biological doses <49Gy and ≥49Gy were 34.3%, 54.4% (P = 0.001) and 69.7%, 77.1% (P = 0 .009). Of the 128 patients who had a pre-correction BED of 79-91 Gy, the total duration of treatment was ≤56 days and ≥56 days of 3?