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Objective:To investigate the role and the clinical significance of anti-zona pellucidaantibody (AzpAb) and tumor necrosis factor-α(TNF-α),γ-interferon(IFN-γ) and inter-leukin-2 (IL-2) in sera from patients with premature ovarian failure (POF).Methods:The AzpAb in the serum of POF patient was analyzed by means ofELISA.The levels of TNF-α,IL-2 and IFN-γ in the serum were determined by meansof radioimmunoassay (RIA).Results:The level of serum AzpAb in the POF patients was significantly higher thanthat of the normal controls(P<0.001).The levels of TNF-α and IL-2 were significantlyreduced (P<0.001),and the level of IFN-γ was significantly elevated (P<0.01).Thelevels of above three cytokines in AzpAb positive group were significantly higher thanthose of the negative group in POF patients.Conclusion:This study suggested that AzpAb,TNF-α,IFN-γ and IL-2 might playimportant roles in the pathogenesis of autoimmune POF.
Objective: To investigate the role and the clinical significance of anti-zona pellucidaantibody (AzpAb) and tumor necrosis factor-α (TNF-α), γ-interferon (IFN- γ) and inter-leukin-2 Sera from patients with premature ovarian failure (POF). Methods: The AzpAb in the serum of POF patient was analyzed by means of ELISA. The levels of TNF-α, IL-2 and IFN-γ in the serum were determined by means of radioimmunoassay RIA) .Results: The level of serum AzpAb in the POF patients was significantly higher thanthat the normal controls (P <0.001). The levels of TNF-α and IL-2 were significantlyreduced (P <0.001), and the level of The levels of above three cytokines in AzpAb positive group were significantly higher thanthose of the negative group in POF patients. Confc: This study suggests that AzpAb, TNF-a, IFN-γ and IL -2 might playimportant roles in the pathogenesis of autoimmune POF.