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目的:探讨基质金属蛋白酶-7(MMP-7)蛋白和Fas蛋白在胃癌组织中的表达、相互关系及意义.方法:应用免疫组化方法检测了82例胃癌组织及30例周边正常胃黏膜中MMP-7和Fas的表达情况.结果:胃癌组织中MMP-7蛋白阳性率显著高于正常胃黏膜(73.2%vs10%,P<0.001);正常胃黏膜中Fas蛋白阳性率显著高于胃癌组织(39.1%vs93.3%,P<0.001).MMP-7阳性表达率与淋巴结转移、TNM分期显著相关(P<0.001),而与肿瘤细胞分化程度无显著性相关.Fas蛋白阳性表达率与肿瘤细胞分化程度显著相关(P<0.05),而与淋巴结转移、TNM分期无显著性相关.胃癌组织中MMP-7与Fas表达具有显著等级负相关(r=-0.597,P<0.001).结论:MMP-7与Fas表达胃癌的生物学行为密切相关,且两者之间的表达强度具有显著等级负相关.
Objective: To investigate the expression, correlation and significance of MMP-7 and Fas protein in gastric cancer.Methods: 82 cases of gastric carcinoma and 30 cases of normal gastric mucosa were detected by immunohistochemistry The positive rate of MMP-7 and Fas in gastric cancer tissues was significantly higher than that in normal gastric mucosa (73.2% vs10%, P <0.001). The positive rate of Fas protein in normal gastric mucosa was significantly higher than that in normal gastric mucosa (39.1% vs93.3%, P <0.001) .The positive expression rate of MMP-7 was significantly correlated with lymph node metastasis and TNM stage (P <0.001), but not with the degree of tumor cell differentiation (P <0.05), but not with lymph node metastasis and TNM stage, but there was a significant negative correlation between the expression of MMP-7 and Fas in gastric cancer (r = -0.597, P <0.001) .Conclusion : MMP-7 is closely related to the biological behavior of Fas-expressing gastric cancer, and there is a significant negative correlation between the expression intensity of MMP-7 and gastric cancer.