胍乙啶和氢氯噻嗪分别为有效的抗高血压和利尿药,临床上通常使用这两种药物的复方制剂。本文报道了在玻璃碳电极上利用氧化怍用,通过高效液相色谱-电流检测技术测定胍乙啶和氢氯噻嗪复方制剂的分析方法。仪器及条件:高压液相层析系统由泵、进样器、装有玻璃碳电极的聚三氟乙烯测定池、辅助铂电极、Ag/AgCl参比电极、电流检 Guanethidine and hydrochlorothiazide, respectively, are effective antihypertensive and diuretic drugs, the clinical use of these two drugs usually compound. In this paper, an analytical method for the determination of guanethidine and hydrochlorothiazide in coumarin with glassy carbon electrode by high performance liquid chromatography-current detection was reported. Equipment and conditions: High pressure liquid chromatography system consists of a pump, injector, polytetrafluoroethylene cell with glassy carbon electrode, auxiliary platinum electrode, Ag / AgCl reference electrode, amperometric