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应用抗人Ｔ细胞单克隆抗体ＣＤ（ＣｌｕｓｔｅｒｓｏｆＤｉｆｆｅｒｅｎｔｉａｔｉｏｎ）系列，对慢性肺心病的急发期２０例和缓解期１２例及正常对照组１７例的Ｔ细胞亚群的变化进行观察对比。对部分病人的的血气变化及植物血凝素（ＰＨＡ）皮试与ＣＤ４／ＣＤ８比值变化的相关性进行了分析。结果表明，慢性肺心病急发期ＣＤ４细胞减少，ＣＤ４／ＣＤ８比值降低，而在缓解期Ｔ细胞亚群没有明显变化；ＣＤ４／ＣＤ８比值变化分别与动脉血氧分压（ＰａＯ２）及动脉血氧饱和度（ＳａＯ２）呈正相关；多数急发期病人（１０／１２）ＰＨＡ皮试低于正常。说明慢性肺心病在急发期存在Ｔ细胞亚群的异常和细胞免疫功能降低，这种改变可能继发于机体的缺氧状态。
The anti-T cell monoclonal antibody CD (ClustersofDifferentiation) series, chronic pulmonary heart disease in 20 cases of acute and 12 cases of remission and control group of 17 cases of T cell subsets changes were observed and compared. The correlation between blood gas changes in some patients and changes of skin PHA test and CD4 / CD8 ratio was analyzed. The results showed that in the acute phase of chronic pulmonary heart disease, the number of CD4 cells decreased and the ratio of CD4 / CD8 decreased while there was no significant change in T cell subsets during remission. The changes of CD4 / CD8 ratio were correlated with PaO2 and arterial oxygenation Saturation (SaO2) was positive correlation; PHA skin test in most patients with acute phase (10/12) was lower than normal. Chronic pulmonary heart disease in patients with abnormal T cell subsets and cellular immune function decline, this change may be secondary to the body’s hypoxia.