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免疫相关性疾病包括过敏性疾病和自身免疫性疾病等。过敏性疾病以速发型过敏反应为主,而自身免疫性疾病是机体对自身抗原发生免疫反应而导致自身组织器官损害的疾病。研究认为蠕虫感染率的下降很可能与免疫相关性疾病的增加密切相关。本文综述了蠕虫感染对哮喘、多发性硬化、系统性红斑狼疮、类风湿关节炎、炎症肠病和I型糖尿病等的免疫保护机制,包括Th1转为Th2表型的改变及上调T型和B型调节性细胞表型的表达等,探讨其临床应用前景和存在的问题。
Immune related diseases include allergic diseases and autoimmune diseases. Allergic diseases are mainly immediate hypersensitivity reactions, whereas autoimmune diseases are diseases in which the body’s immune response to its own antigens causes damage to its own tissues and organs. The study concluded that the decline in the rate of worm infection is likely to be closely related to the increase in immune-related diseases. This article reviews the mechanisms of immune protection against helminth infection in asthma, multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease and type I diabetes mellitus, including the change of Th1 to Th2 phenotype and upregulation of T and B Type regulatory cell phenotype expression, to explore its clinical application prospects and problems.