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近年临床研究表明内耳功能障碍与多种免疫性疾病存在着明显的关系,但其病理生理机制不明,因此有必要建立适当的动物模型进行深入的研究。作者用健康、或龄豚鼠分为对照组(12只)、初次免疫反应纽(初免组11只)和再次免疫反应组(再免组9只),接种KLH(钥孔槭血蓝素)前抽血测抗KLH抗体和测CM(耳蜗微音电位)和AP(Ⅷ脑神经N_1复合动作电位)。于右侧耳蜗基部钻一直径250μm的小孔进入鼓阶,抽外淋巴15～20μl作抗KLH测定,换管缓注
In recent years, clinical studies have shown that inner ear dysfunction and a variety of immune diseases there is a clear relationship, but its pathophysiology is unknown, it is necessary to establish an appropriate animal model for further study. The subjects were divided into control group (n = 12), primary immunological reaction group (n = 11) and re-immunization group (n = 9) Before blood test anti-KLH antibodies and CM (cochlear microphones potential) and AP (Ⅷ cranial nerve N_1 composite action potential). On the right cochlear base, a small hole with a diameter of 250 μm was drilled into the scala tympani. Extrapleural lymphatic vessels were treated with anti-KLH