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目的:探讨大黄蛰虫丸治疗下肢深静脉血栓形成(DVT)后遗症的作用机理。方法:观察大黄蛰虫丸对深静脉血栓形成动物模型的ET,6-Keto-PGF1α的影响。结果:大黄蛰虫丸能够降低血清中ET,升高血清中6-Keto-PGF1α的含量,与通塞脉片组无明显差异。结论:大黄蛰虫丸治疗DVT后遗症可能与降低血清中ET含量,升高6-keto-PGF1α含量有关。
Objective: To explore the mechanism of the treatment of deep vein thrombosis (DVT) sequelae caused by Dahuangqichong Pill. Methods: To observe the effect of Dahuangqichong Pill on ET and 6-Keto-PGF1α in animal model of deep vein thrombosis. RESULTS: Dahuangqichong Pill could reduce ET in serum and increase the content of 6-Keto-PGF1α in serum, which was not significantly different from Tongsaimai tablet group. Conclusion: The treatment of DVT sequelae by Dahuangqichong Pill may be related to the decrease of serum ET content and increase of 6-keto-PGF1α content.