胃肠道间质瘤(GIST)是消化系统最常见间叶源性肿瘤，具有潜在恶性倾向。随着生活习惯的变化和仪器设备的更新，GIST发病率和检出率逐年升高，因而备受关注，但其临床表现无特征性。目前主要通过CT、MRI等影像学技术初诊，病理学检测为其诊断的金指标。近年来随着免疫组化技术和基因技术的发展，免疫标志物和基因检测对GIST的诊断日趋重要。笔者对GIST诊断技术进展进行综述。“,”Gastrointestinal stromal tumor(GIST) is the most common mesenchymal tumor in the digestive system, with potential malignant tendency.With the change of living habits and the update of instruments and equipments, the morbidity and detection rate of GIST have been increased year by year, attracting much attention.However, its clinical manifestations are not characteristic.At present, primary diagnosis is mainly made by imaging techniques such as CT and MRI, and pathological diagnosis is the gold index.In recent years, with the development of immunohistochemical technology and gene technology, immune markers and gene detection play an increasingly important role in the diagnosis of GIST.This paper reviews the progress of GIST diagnostic techniques.