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目的：研究 Ｉ Ｃ Ａ Ｍ １ 表达与膀胱癌生物学行为的关系。方法：应用免疫组化法对 ４０ 例石蜡包埋的膀胱癌标本中 Ｉ Ｃ Ａ Ｍ １ 表达进行检测。结果：膀胱癌组织中 Ｉ Ｃ Ａ Ｍ １ 表达阳性率为８８％ ，而安全缘组织中阳性率为 １６％ ，两者之间差异非常显著，且 Ｉ Ｃ Ａ Ｍ １ 的表达与膀胱癌的临床分期与病理分级呈负相关，即随膀胱癌的临床分期和病理分级的增高 Ｉ Ｃ Ａ Ｍ １ 表达降低。结论：膀胱癌组织 Ｉ Ｃ Ａ Ｍ １ 表达检测可以作判定患者机体免疫功能状态、治疗效果及预后观察的客观指标。
Objective: To study the relationship between I C A M 1 expression and biological behavior of bladder cancer. Methods: The expression of I C A M 1 in 40 paraffin-embedded bladder cancer specimens was detected by immunohistochemistry. Results: The positive rate of I C A M 1 expression in bladder cancer was 88%, while the positive rate in the safety margin was 16%. The difference between the two groups was significant, and the expression of I C A M 1 was positively correlated with the expression of bladder cancer The clinical stage and pathological grade was negatively correlated, that with the clinical stage and pathological grade of bladder cancer increased I C A M 1 expression decreased. Conclusion: The detection of I C A M 1 expression in bladder cancer can be used as an objective index to determine the status of immune function, therapeutic effect and prognosis in patients with bladder cancer.