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目的观察四妙丸联合西药治疗活动期类风湿关节炎的临床疗效。方法将40例活动期类风湿关节炎患者随机分为两组,对照组20例,口服甲氨喋呤片、扶他林片;治疗组20例,在对照组的基础上口服中药四妙丸,两组均连续用药3个月。观察两组患者治疗前后临床症状、体征以及血沉(ESR)、C反应蛋白(CRP)及类风湿因子(RF)的变化以及血液流变学各项指标的变化情况。结果治疗组总有效率95.0%,对照组总有效率75.0%,治疗组明显优于对照组(P<0.05);两组治疗后各项临床症状、体征以及ESR、CRP、RF、血液流变学各项指标均较治疗前有明显改善(P<0.05),两组治疗后比较差异亦有统计学意义(P<0.05)。结论四妙丸治疗活动期类风湿关节炎有效,疗效优于甲氨喋吟片。
Objective To observe the clinical efficacy of Simiao Pill combined with western medicine in the treatment of active rheumatoid arthritis. Methods Forty patients with active rheumatoid arthritis were randomly divided into two groups, the control group of 20 patients, oral methotrexate tablets, Futailin tablets; the treatment group of 20 patients on the basis of the control group oral Chinese medicine Simiao pill, two Group were continuous medication for 3 months. The changes of clinical symptoms, signs, ESR, CRP and RF in both groups before and after treatment were observed. The changes of hemorheology indexes were also observed. Results The total effective rate was 95.0% in the treatment group and 75.0% in the control group, which was significantly better in the treatment group than in the control group (P <0.05). The clinical symptoms and signs, ESR, CRP, RF, blood rheology The indexes of all studies were significantly improved (P <0.05), and the differences between the two groups after treatment were also statistically significant (P <0.05). Conclusion Si Miao Wan active rheumatoid arthritis treatment effective, the effect is better than the methotrexate Yin film.