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目的:评价十味金黄膏联合中药外洗方治疗急性甲沟炎的疗效。方法:将符合入选标准的2019年1-12月中国中医科学院西苑医院126例急性甲沟炎患者按随机数字表法分为3组，每组42例。治疗组采用十味金黄膏联合中药外洗方治疗，对照组1组采用中药外洗方，对照2组外用莫匹罗星软膏。3组均治疗2周，随访2个月。采用ELISA法检测血清CRP水平，采用全自动血液分析仪检测中性粒细胞百分比(neutrophil percentage, NEU%)，评价临床疗效。结果:治疗组总有效率为90.5%(38/42)、对照1组为71.4%(30/42)、对照组2组为66.7%(28/42)，3组比较差异有统计学意义(n χ2＝7.350，n P＝0.025)。治疗后，治疗组血清CRP水平及NEU%均低于对照1组、对照2组(n F值分别为6.482、33.619，n P值均<0.001)。随访2个月，对照1组慢性甲沟炎发生率为50.0%(6/12)、对照2组为57.1%(8/14)，治疗组无患者迁延为慢性甲沟炎。3组慢性甲沟炎发生率比较，差异有统计学意义(n χ2＝9.355，n P＝0.009)。n 结论:十味金黄膏联合中药外洗方可促进急性甲沟炎患者炎性细胞水平的下降，降低慢性甲沟炎的发生率，提高临床疗效。“,”Objective:To evaluate the clinical efficacy of n Shiwei-Jinghuang Ointment combined with Chinese herbal external washing prescription in the treatment of acute paronychia.n Methods:A total of 126 patients with acute paronychia in Xiyuan Hospital of China Academy of Chinese Medical Sciences from January to December 2019, who met the inclusion criteria, were divided into 3 groups according to the random number table method (42 in each group). The treatment group was treated with n Shiwei-Jinghuang Ointment combined with Chinese herbal external washing prescription. The control group 1 and group 2 were simply applied with Chinese herbal external washing prescription and mupirocin ointment, respectively. All groups were treated for 2 weeks and followed up 2 months. Serum CRP level was determined by ELISA method, and neutrophil percentage (NEU%) was measured by automatic hematology analyzer. The subsided time of red swelling and inflammatory exudation in nail groove of the paronychia patients were observed and recorded.n Results:The total effective rate was 90.5% (38/42) in the treatment group, 71.4% (30/42) in the control group 1 and 66.7% (28/42) in the control group 2. The statistical difference were significant among three groups (n χ2=7.350, n P=0.025). After treatment, the serum CRP level and NEU% in three groups were decreased (n P<0.01), and the serum CRP and NEU% level in treatment group were significantly lower than those in the control group 1 and group 2 (n F values were 6.482, 33.619, respectively, all n Ps<0.001). After 2 months of follow-up, the incidences of chronic paronychia were 50.0% (6/12) and 57.1% (8/14) in control group 1 and group 2, respectively, but no chronic paronychia occurred in the treatment group. The difference among three groups was statistically significant (n χ2=9.355, n P=0.009).n Conclusion:The combination of n Shiwei-Jinghuang Ointment and Chinese herbal external washing prescription can promote paronychia red swelling, reduce the inflammatory exudation time and the incidence of chronic paronychia, effectively improve the in vivo decrease inflammation index and clinical efficacy.n