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目的研究低分子肝素(LMWH)治疗进展型脑血栓的疗效及抗凝纤溶功能。方法48例患者随机分成治疗组与对照组各24例。前者除常规治疗外,应用了LMWH0.4ml腹壁皮下注射,每日2次,连续10d。结果LMWH可阻止进展型脑血栓症状的进一步加重,在短时间内改善伤残程度,临床疗效明显(P<0.01),凝血酶原时间较治疗前延长(P<0.01),血小板粘附率较治疗前降低(P<0.01),无明显不良反应。结论进展型脑血栓早期给予抗凝治疗有助于改善预后,降低病死率和致残率,未发现有明显的不良反应,安全系数高。
Objective To investigate the therapeutic effect and anticoagulant fibrinolytic activity of low molecular weight heparin (LMWH) for advanced cerebral thrombosis. Methods 48 patients were randomly divided into treatment group and control group, 24 cases each. The former in addition to conventional treatment, the application of LMWH0.4ml abdominal subcutaneous injection, twice daily for 10 days. Results LMWH could prevent further worsening of symptoms of progressive thrombosis and improve the degree of disability in a short period of time. The clinical effect was significant (P <0.01). Prothrombin time was longer than that before treatment (P <0.01) Before treatment decreased (P <0.01), no significant adverse reactions. Conclusion Early anticoagulant therapy of advanced cerebral thrombosis can improve prognosis, reduce mortality and morbidity, no obvious adverse reactions and high safety factor.