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目的:研究喉鳞状细胞癌组织IL-10及单核细胞、肿瘤相关巨噬细胞在肿瘤微环境中的分布情况。方法:采用免疫组织化学方法对IL-10、CD14、CD68在46例喉鳞状细胞癌组织中的表达进行研究,并探讨三者与临床病理参数之间的关系。结果:喉鳞状细胞癌组织中IL-10、CD14、CD68的表达与临床分期、T分期明显相关(均P<0.01),IL-10、CD14与淋巴结转移均有关(均P<0.01),CD68与病理分化程度相关(P<0.05)。IL-10和CD14在喉鳞状细胞癌组织中的表达呈正相关(P<0.01)。结论:喉鳞状细胞癌组织中IL-10、单核细胞、肿瘤相关巨噬细胞的浸润程度与肿瘤的进展程度相关,IL-10的表达与单核细胞有一定关系。
Objective: To study the distribution of IL-10, monocytes and tumor-associated macrophages in the tumor microenvironment of laryngeal squamous cell carcinoma. Methods: The expressions of IL-10, CD14 and CD68 in 46 cases of laryngeal squamous cell carcinoma were studied by immunohistochemistry. The relationship between them and clinicopathological parameters was also explored. Results: The expressions of IL-10, CD14 and CD68 in laryngeal squamous cell carcinoma were significantly correlated with clinical stage and T stage (all P <0.01), while IL-10 and CD14 were correlated with lymph node metastasis (all P <0.01) CD68 was correlated with the degree of pathological differentiation (P <0.05). The expression of IL-10 and CD14 in laryngeal squamous cell carcinoma was positively correlated (P <0.01). Conclusion: The degree of infiltration of IL-10, monocytes and tumor-associated macrophages in laryngeal squamous cell carcinoma is related to the degree of tumor progression. The expression of IL-10 is related to mononuclear cells.