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目的：调查重症监护病房（ICU）慢性阻塞性肺疾病急性加重期（AECOPD）患者五年的病原菌分布、耐药性及变迁情况。方法回顾性分析2008~2009年和2013~2014年本：ICU收治的AECOPD患者的感染情况。结果2008~2009年共分离菌株39株，G-菌29株（74.36%），G+菌6株（15.38%），铜绿假单胞菌对亚胺培南耐药率41.67%，鲍曼不动杆菌对亚胺培南耐药率为0%，金黄色葡萄球菌检出率为10.26%。2013~2014年共分离菌株86株，G-菌62株（72.09%），G+菌7株（8.14%），真菌17株（19.77%）；分离的铜绿假单胞菌对亚胺培南耐药率83.33%，鲍曼不动杆菌对亚胺培南耐药率为78.38%，金黄色葡萄球菌检出率为2.33%。结论我：ICUAECOPD患者鲍曼不动杆菌感染率增加，耐药性有明显增高趋势。ICU需要合理使用抗菌药物，密切监测病原菌耐药性变化。“,”Objective To investigate the transition of bacterial distribution and drug resistance isolated from AECOPD patients in ICU during five years. Methods Retrospect ively analyze the pathogenic bacteria isolated from AECOPD patients in ICU in 2008-2009 and 2013~2014. Results In 2008~2009, a total of 39 bacterial strains were col ected,including 29(74.36%)strains of gram-negative bacteria and 6(15.38%)strains of gram-positive bacteria.The resistance rate of Pseudomonas aeruginosa to imipenem was 41.67%, the resistance rate of Acine-tobacter baumanni was 0%.The detection rate of Staphylococcus aureus was 10.26%. In 2013~2014, a total of 86 bacterial strains were col ected,including 62 (72.09%)strains of gram-negative bacteria ,7 (8.14%)strains of gram-positive bacteria and 17 (19.77%)strains of Blastomyces.The resistance rate of Pseudomonas aeruginosa to imipenem was 83.33%, the resistance rate of Acinetobacter baumanni was 78.38%. The detection rate of Staphylococcus aureus was 2.33%. Conclusion The infection rate of Acinetobacter baumanni increased. Bacterial resistance is more serious. The use of antibiotics should be rational and the trend of bacterial resistance should be monitored closely.