目的:制备表皮生长因子漱口水及探讨鼠表皮生长因子(mEGF)在朵贝氏溶液中的活性和稳定性。方法:在朵贝氏溶液中加入mEGF及庆大霉素制备漱口水,采用MTT法对mEGF的活性及稳定性进行研究。结果;本制剂放置4℃冰霜内6 mo,mEGF活性降低小于10%,mEGF对热较稳定,并且在朵贝氏溶液中活性及稳定性不受影响。结论:本制剂配方合理、稳定,适应于多种口腔疾病的治疗。 Objective: To prepare epidermal growth factor mouthwash and investigate the activity and stability of mouse epidermal growth factor (mEGF) in Dover ’s solution. Methods: MEGF and gentamicin were added into Doberman ’s solution to prepare mouthwash. The activity and stability of mEGF were studied by MTT method. The results showed that the activity of mEGF was less than 10% when the preparation was placed in frost at 4 ℃ for 6 months, and the activity of mEGF was stable to heat. The activity and stability of mEGF in Dobre’s solution were not affected. Conclusion: The preparation formula is reasonable and stable, suitable for the treatment of a variety of oral diseases.