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目的:研究氟桂利嗪是否对急性缺血性梗死缺血半暗带的受损神经元细胞具有一定的保护作用。方法:把卫生部北京医院收治符合临床及脑核磁共振检查诊断的急性缺血性梗死的60例患者分为氟桂利嗪组与对照组各30例,并在治疗前、治疗后3,6及12h分别进行脑弥散核磁共振检查,观察缺血核心部位及半暗带面积的变化。结果:氟桂利嗪组在治疗后12h半暗带面积为(0.40±0.23)cm2,与本组治疗前(2.05±0.77)cm2及治疗12h后对照组(0.71±0.22)cm2相比较,缺血半暗带均有明显改善(P<0.001)。同时缺血核心部位的面积也明显缩小(P<0.001)。结论:氟桂利嗪对急性缺血性梗死缺血性半暗带的脑组织具有一定的保护作用。
OBJECTIVE: To investigate whether flunarizine can protect neurons from damaged ischemic penumbra in acute ischemic infarction. Methods: Sixty patients with acute ischemic infarction who were diagnosed by clinical and cerebral magnetic resonance imaging were divided into flunarizine group and control group (n = 30) .Before treatment, 3,6 And 12h respectively diffuse brain MRI examination to observe the changes of ischemic core area and penumbra area. Results: Compared with the control group (0.71 ± 0.22) cm2 in the flunarizine group at 12 hours after treatment, the area of the penumbra was (0.40 ± 0.23) cm2, Blood penumbra were significantly improved (P <0.001). At the same time, the area of ischemic core was also significantly reduced (P <0.001). Conclusion: Flunarizine can protect brain tissue of ischemic penumbra in acute ischemic infarction.