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目的 :评价博莱霉素对难治性胸腔积液的疗效及毒性。方法 :42例经两种以上方法治疗无效的恶性胸腔积液患者应用博莱毒素胸腔内给药治疗。结果 :有效率 6 1.90 % (2 6 / 42 ) ,完全缓解率 47.6 2 % (2 0 / 42 )。不良反应有发热、胸痛 ,但少见而轻微。Karnofsky评分从平均 6 5分升至 85分 (P <0 .0 1)。 结论 :对于其它方法治疗失败的恶性胸腔积液可采用博莱霉素治疗。
Objective: To evaluate the efficacy and toxicity of bleomycin on refractory pleural effusion. Methods: Forty-two patients with malignant pleural effusion treated by two or more methods were treated with intrapleural injection of Boleysin. Results: The effective rate was 6.90% (26/42) and the complete remission rate was 47.6% (20/42). Adverse reactions have fever, chest pain, but rare and mild. The Karnofsky score rose from an average of 6 5 points to 85 points (P <0.01). Conclusions: Bleomycin is the treatment of malignant pleural effusion that has failed to be treated by other methods.