近几年随着分子生物学的惊人进展,已弄清了人类生长激素(hGH)的遗传基因结构,并用大肠杆菌生产的hGH和遗传基因组互换后繁殖了“超重”小白鼠。进而确定了hGH释放因子(GRF)和促生长因子(So-matomedin,SM)的一级结构,阐明了生长现象的生理调节机制和生长发育障碍的病因等,以这些知识为基础使人感到进入了一个新阶段。生长发育是儿科学的中心内容,今后数年围绕hGH的科学研究,将是儿科学面临的新的挑战,本文从儿科观点来叙述其最新进展。 In recent years, with the amazing progress of molecular biology, the genetic structure of human growth hormone (hGH) has been clarified and “overweight” mice are bred after being exchanged with the genome of hGH produced by E. coli. The primary structure of hGH release factor (GRF) and So-matomedin (SM) was identified, and the physiological regulation mechanism of growth phenomenon and the etiology of growth and development disorders were clarified. Based on these knowledge, A new stage. Growth and development are the center of pediatrics. The scientific research surrounding hGH in the coming years will be a new challenge for pediatrics. This article describes the latest progress in pediatrics.