HBeAg和抗-HBe是乙型肝炎的经典标志。制备诊断试剂用的HBeAg可从人血浆中获得,但用基因工程方法生产则是更安全、有效和廉价的途径。HBeAg和HEcAg同为HBV C区基因编码,但直接用大肠杆菌合成HBeAg文献上尚未见报导。本研究 HBeAg and anti-HBe are the hallmarks of hepatitis B. HBeAg for the preparation of diagnostic reagents can be obtained from human plasma, but it is safer, more effective and less expensive to produce by genetic engineering. Both HBeAg and HEcAg are encoded by the HBV C region, but no direct report has been reported on the synthesis of HBeAg by E. coli. this research