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目的:通过观察增强型体外反博(EECP)联合药物治疗对不稳定型心绞痛(UA)患者炎症因子、hs-CRP的变化情况,探究EECP对UA的治疗效果。方法:选择2009年1月至2009年10月在惠东县人民医院的140例UA患者,随机分成观察组和对照组,每组70例,对照组采用β受体阻滞剂、硝酸盐制剂、双联抗血小板、低分子肝素、钙拮抗剂和他汀类调脂药物等常规药物进行治疗,观察组患者在常规药物治疗的基础上加用EECP治疗。对两组患者治疗效果进行评价,观察患者心电图、运动耐量、心绞痛症状等的变化情况,并比较患者炎症因子TNFα、IL-6和hs-CRP的水平变化。结果:观察组治疗后心绞痛改善有效率达92.9%,对照组治疗有效率达70.0%,观察组治疗效果显著优于对照组,差异具有统计学意义(P<0.05);治疗前观察组和对照组心电图、6 min步行距离(6MWD)差异无统计学意义,治疗后观察组各指标均优于对照组,差异具有统计学意义(P<0.05);治疗前两组患者TNFα、IL-6和hs-CRP的水平差异无统计学意义(P>0.05),治疗1个月后观察组TNFα、IL-6和hs-CRP的水平显著低于对照组,差异具有统计学意义(P<0.05)。结论:EECP对UA的治疗效果显著,能够减少UA患者的疼痛,这可能与CEEP对炎症因子和hs-CRP的水平的显著降低作用有关。
Objective: To observe the changes of inflammatory factors and hs-CRP in patients with unstable angina pectoris (UA) treated with enhanced EECP and explore the therapeutic effect of EECP on UA. Methods: One hundred and forty patients with UA in Huidong County People’s Hospital from January 2009 to October 2009 were randomly divided into observation group and control group, 70 cases in each group. The control group received β-blocker and nitrate , Dual antiplatelet, low molecular weight heparin, calcium antagonist and statin lipid-lowering drugs and other conventional drugs for treatment, the observation group of patients on the basis of conventional drug therapy plus EECP treatment. The therapeutic effects of the two groups of patients were evaluated. The changes of electrocardiogram, exercise tolerance and angina pectoris were observed. The levels of inflammatory cytokines TNFα, IL-6 and hs-CRP in patients were also compared. Results: The improvement rate of angina pectoris in observation group was 92.9% after treatment, the effective rate of control group was 70.0%. The treatment effect in observation group was significantly better than that in control group (P <0.05). Before treatment, the observation group and control group There was no significant difference between 6MWD group and 6MWD group after treatment (P <0.05). After treatment, the indexes in observation group were better than those in control group (P <0.05). The levels of TNFα, IL-6 and (P> 0.05). The levels of TNFα, IL-6 and hs-CRP in the observation group after 1 month of treatment were significantly lower than those in the control group (P <0.05) . Conclusion: EECP treatment of UA significantly, can reduce the pain of UA patients, which may be related to CEEP on the level of inflammatory cytokines and hs-CRP significantly reduced.