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目的观察分析喜炎平注射液、匹多莫德口服液对小儿手足口治疗效果。方法将2011年1月至11月确诊的手足口病入院患儿93例随机分为两组,对照组46例,联用组47例。两组患者均给予隔离、退热、对症治疗和利巴韦林抗病毒治疗。对照组加用喜炎平注射液按5mg/(kg.d)计算用量,加入5%葡萄糖液100ml中静脉滴注。联用组在对照组基础上加口服匹多莫德口服液400mg/次,2次/d。结果联用组患儿经治疗后,在退热时间、溃疡愈合时间、皮疹消退时间以及治愈率方面均优于对照组,具有统计学意义(P<0.05)。结论喜炎平注射液和匹多莫德口服液联用有良好的协同作用,具有治愈率高、改善临床症状、减少并发症等优点,值得临床推广应用。
Objective To observe and analyze the effect of Xiyanping Injection and Pidotimod on children hand-foot-mouth treatment. Methods Ninety-three children hospitalized with hand-foot-mouth disease diagnosed from January to November 2011 were randomly divided into two groups: control group (n = 46) and combination group (n = 47). Both groups were given isolation, antipyretics, symptomatic treatment and ribavirin antiviral therapy. The control group plus Xiyanping injection by 5mg / (kg.d) calculated dosage, adding 5% glucose solution 100ml intravenous infusion. Combination group in the control group plus oral pidotimod oral solution 400mg / times, 2 times / d. Results Compared with the control group, the children in the combination group were significantly better in the antipyretic time, ulcer healing time, rash subsidence time and cure rate (P <0.05). Conclusion Xiyanping injection combined with pidotimod oral solution has a good synergistic effect, with the advantages of high cure rate, improvement of clinical symptoms and reduction of complications, which is worthy of clinical application.