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磁共振成像(MRI)是一项能够提供高分辨生理和解剖信息的技术,该技术不使用放射性物质,对人体危害较小,解决了糖尿病在诊断和治疗中所遇到的难题(如胰岛细胞体积小、分散,活体难检测等),因此国内外专家利用MRI活体成像技术对糖尿病的早期诊断、分期和治疗进行了系列研究。一、MRI在自身免疫攻击中的应用由于自身免疫反应破坏β细胞而产生胰腺炎,进而导致1型糖尿病(T1DM)的发病。胰腺组织活检可以检测胰腺炎,但是组织活检具有创伤性,因而被患者抵制。利用免疫排斥反应及炎症反应细胞特异性分子,采用分子成像的方法活体检测免疫排斥反应,比现行的组织活检更能反映排斥反应初期的变化,该研究已经取得了初步的进展。Moore等首次利用超微磁性颗粒CLIO-Tat标记淋巴细胞,使用MRI技术可以活体检测移植到大鼠胰腺中的淋巴细胞和免疫细胞的渗透,该参数可作为糖尿病发病的一个早期参数。
Magnetic Resonance Imaging (MRI) is a technology that provides high-resolution physiological and anatomical information that does not use radioactive substances and is less harmful to humans and solves the problems encountered in the diagnosis and treatment of diabetes such as islet cells Small size, scattered, difficult to detect live, etc.), so experts at home and abroad using MRI live imaging technology for early diagnosis of diabetes, staging and treatment of a series of studies. First, the application of MRI in autoimmune attacks Because of their immune response to destroy β cells and produce pancreatitis, which led to the incidence of type 1 diabetes (T1DM). Pancreatic biopsies detect pancreatitis, but tissue biopsies are traumatic and are countered by the patient. Immunological rejection and inflammatory response cell-specific molecules, the molecular imaging method for the detection of immune rejection in vivo, than the current biopsy better reflect the early rejection changes, the research has made initial progress. For the first time, Moore et al. Used CLIO-Tat to label lymphocytes and use MRI to detect the infiltration of lymphocytes and immune cells transplanted into the rat pancreas on the living body. This parameter can serve as an early parameter for the onset of diabetes.