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目的研究观察三餐前门冬胰岛素联合中效胰岛素对妊娠糖尿病的临床疗效。方法 80例妊娠糖尿病患者,随机分成对照组与观察组,各40例。对照组给予中效胰岛素进行治疗,观察组在此基础上联合门冬胰岛素进行治疗,比较两组治疗效果。结果治疗后,观察组患者空腹血糖、餐后1 h血糖、餐后2 h血糖、糖化血红蛋白(HbA1c)水平均明显优于对照组,差异具有统计学意义(P<0.05)。观察组不良结局发生率为20.0%,明显低于对照组的57.5%,差异具有统计学意义(P<0.05)。结论三餐前门冬胰岛素联合中效胰岛素治疗妊娠期糖尿病,能够有效控制患者血糖,降低母婴妊娠不良结局发生率,值得临床推广。
Objective To observe the clinical efficacy of insulin aspart aspart 3 combined with mid-acting insulin on gestational diabetes mellitus. Methods 80 cases of gestational diabetes mellitus were randomly divided into control group and observation group, 40 cases each. The control group was treated with middle-acting insulin, and the observation group was treated with insulin aspart on the basis of the above. The therapeutic effect was compared between the two groups. Results After treatment, fasting blood glucose, postprandial blood glucose 1 h, postprandial blood glucose 2 h, HbA1c levels in observation group were significantly better than those in control group (P <0.05). The incidence of adverse outcomes in the observation group was 20.0%, significantly lower than 57.5% in the control group, the difference was statistically significant (P <0.05). Conclusions Three meals of insulin aspart as well as middle-acting insulin in gestational diabetes mellitus can effectively control the blood sugar and reduce the incidence of adverse pregnancy outcomes in pregnant women and infants, which is worthy of clinical promotion.