美《纽约时报》1982年4月13日报道:根据最近一些报道说,世界各地广泛使用的一类药物对新近发现的一种遗传性酶缺乏的人会产生有害的作用,这类药物即β-阻滞剂,用于治疗高血压、心脏病和心律不齐等。在正常情况下β-阻滞剂减慢心律,但有遗传性酶缺乏的人,对普通剂量的β阻滞剂会产生过度的反应,心脏跳动得非常缓慢,结果产生疲劳、眩晕和昏厥。大多数药物最终被人体的生化系统代谢,但缺乏β-阻滞剂所必需的酶的病人,药物不能 The U.S. New York Times reported on April 13, 1982: According to recent reports, a widely used class of drugs around the world have a deleterious effect on newly discovered individuals with an inherited enzyme deficiency. These drugs, known as β - Blockers, used to treat high blood pressure, heart disease and arrhythmia. Beta-blockers slow down the heart rate under normal circumstances, but people with inherited enzyme deficiency react excessively with normal-dose beta blockers and the heart beats very slowly resulting in fatigue, dizziness and fainting. Most drugs are eventually metabolized by the body’s biochemical system, but patients lacking the enzyme necessary for beta-blockers can not