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目的观察广泛切除联合氟尿嘧啶局部辅助治疗人类免疫缺陷病毒(HIV)阳性结膜鳞状细胞癌患者的疗效和毒性。方法对已确诊为HIV阳性的结膜鳞状细胞癌进行广泛手术切除,术后辅助1%氟尿嘧啶局部化疗。结果 51例患者进入本研究,中位随访19个月没有复发病例,同时只有部分病例出现化疗相关的轻微眼部刺激症状。结论对于HIV阳性的结膜鳞状细胞癌患者,广泛切除联合术后氟尿嘧啶局部辅助治疗效果好,毒性轻微。
Objective To observe the curative effect and toxicity of extensive excision and fluorouracil topical adjuvant therapy for human immunodeficiency virus (HIV) positive conjunctival squamous cell carcinoma. Methods A wide range of surgical resections of conjunctival squamous cell carcinoma that have been diagnosed as HIV positive were performed. Adjuvant 1% fluorouracil topical chemotherapy was given postoperatively. Results 51 patients entered the study. There was no recurrence after a median follow-up of 19 months. At the same time, only mild cases of chemotherapy-related ocular irritation occurred in some cases. Conclusion For patients with HIV-positive conjunctival squamous cell carcinoma, extensive adjuvant fluorouracil topical adjuvant therapy is effective and has minimal toxicity.