论文部分内容阅读
本文以体外培养的低分化人胃腺癌细胞株SGC－7901为实验模型，采用MTT比色法，观察了β-榄香烯单独及与阿霉素、顺铂联合应用时的细胞毒作用。结果表明，β-榄香烯单独应用对SGC－7901细胞具有一定的抑制作用，其细胞毒指数与药物浓度呈正相关；β-榄香烯与阿霉素或顺铂联合应用则呈现明显的协同效应。上述结果对于临床联合应用β-榄香烯与其它化疗药物治疗胃腺癌具有一定指导意义。
In this paper, in vitro cultured poorly differentiated human gastric adenocarcinoma cell line SGC-7901 was used as an experimental model. MTT assay was used to observe the cytotoxicity of β-elemene alone and in combination with doxorubicin and cisplatin. The results showed that β-elemene alone had a certain inhibitory effect on SGC-7901 cells, and its cytotoxicity index was positively correlated with the drug concentration; β-elemene showed significant synergy with the combination of doxorubicin and cisplatin. effect. The above results have certain guiding significance for the clinical application of β-elemene and other chemotherapeutic drugs for the treatment of gastric adenocarcinoma.