高原环境具有低氧、低气压、寒冷、辐射强等基本特点,其中低氧是影响人类生命活动的主要因素。高原低氧的研究主要集中在急性高原病及高原营养和高原适应方面[1]。20世纪80年代以来高原低氧对药物体内代谢的影响引起广泛关注,低氧条件下机体产生一系列生理性变化,部分为病理性 The plateau environment has the basic characteristics of low oxygen, low pressure, cold, strong radiation, etc., of which hypoxia is the main factor affecting human life activities. Plateau hypoxia research focuses on acute altitude sickness and plateau nutrition and altitude adaptation [1]. The influence of plateau hypoxia on metabolism in the body since the 1980s has aroused widespread concern. Under hypoxic conditions, the body produces a series of physiological changes, some of which are pathological