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近年来对育龄妇女弥漫型毒性甲状腺肿的诊断有所改善。应用放免方法检测血液中激素水平可成功确定该疾病的固有特点:在调节甲状腺功能的促甲状腺素(TSH)水平正常甚至降低时,总的和游离的甲状腺素及三碘甲状腺原氨酸的浓度显著增加。文献资料证明,轻中度本症病人无月经功能障碍,受孕能力不降低。妊娠合并弥漫型毒性甲状腺肿的发生率为0.2~4%,此等病人妊娠时最常并发早期流产、妊毒症、围产期高发病率-胎儿死亡、婴儿发育畸形。
In recent years, the diagnosis of diffuse toxic goiter in women of childbearing age has been improved. The use of radioimmunoassay to detect hormone levels in the blood can successfully determine the intrinsic characteristics of the disease: the total and free thyroxine and triiodothyronine concentrations, when normalizing or even reducing the levels of thyroid-stimulating thyrotrophin (TSH) A significant increase. Documentation shows that patients with mild to moderate menstrual dysfunction, pregnancy ability does not reduce. The incidence of diffuse toxic goiter during pregnancy is 0.2% to 4%. Most of these patients have early miscarriage during pregnancy, pregnancy-induced insomnia, high perinatal morbidity, fetal death and infantile malformation.