制备肠道去污染小鼠动物模型 ,经口感染绿脓杆菌 PA11,同时口饲马齿苋提取液或金银花提取液 2 m g/只 ,2 4h、48h后给予同样药物计量。分离单个菌落 ,影印培养 ,计数消除子。结果显示 :两种药作用2 4h均未获得消除子 ,作用 48h和 72 h R质粒平均消除率马齿苋为 2 .15 %、金银花为 12 .2 5 %。消除子均表现为多重耐药性丢失 Intestinal decontamination animal model was prepared, oral P. aeruginosa PA11, oral purslane extract or honeysuckle extract 2 m g/, 24 h, 48 h after the same drug measurement. Separate single colonies, photocopy culture, count elimination. The results showed that the elimination effect of the two drugs was not achieved after 24 hours and the average elimination rate of the R plasmid was 2.15 % for the 48 h and 72 h R. pylori and 12.25 % for the honeysuckle. Eliminators all show loss of multiple drug resistance