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本文应用免疫扩散法研究了58例各型肾病患者血清β_1A球蛋白浓度及伴有高蛋白尿时昼夜尿中的β_1A球蛋白浓度(注:β_1A球蛋白系具有补体C_3活性的β_1C球蛋白的裂解产物)。一、10例红斑狼疮性肾炎患者中有7例血清中β_1A球蛋白水平下降,3例在正常值以下(100～130毫克％)。其下降程度与疾病活动性有关,当症状改善或治疗获效时血清中β_1A球蛋白随之回升。没有肾损害的红斑狼疮患者同样观察到血清中β_1A球蛋白水平下降,此类患者多属Ⅲ度活动期。其血清IgG水平与β_1A球蛋白浓度呈相反规律性即β_1A球蛋白才平最低时,IgG水平最高。低补体成份的红斑狼疮性肾炎患者即使有高蛋白尿,其尿中β_1A球蛋白排泄量亦极低;有时竟未能测出。作者认为,研究血清中β_1A球蛋白含量有助于对此类疾患的诊断与鉴别诊断,并可用以评价疗效。二、25例慢性肾炎患者血清中β_1A球蛋白水平下降者仅有2例。其下降机理仍在研究中。形态学观察
In this paper, we used immunodiffusion method to study the serum level of β_1A globulin and the concentration of β_1A globulin in diurnal urine with 58 cases of various types of nephropathy (Note: β_1A globulin cleaves β_1C globulin with complement C_3 activity) product). First, in 10 cases of lupus nephritis patients, 7 cases of serum β_1A globulin levels decreased in 3 cases below normal (100 ~ 130 mg%). The degree of decline associated with disease activity, when the symptoms improve or treatment of serum β_1A globulin then rise. Patients with lupus nephropathy also observed a decrease in serum β_1A globulin levels, which are mostly at Ⅲ degree activity. The serum IgG level and β_1A globulin concentration showed the opposite regularity, that is, β_1A globulin was the lowest level, the highest level of IgG. Low complement components of lupus nephritis even in patients with high proteinuria, urinary β_1A globulin excretion is also very low; sometimes unexpectedly failed to measure. The authors believe that the study of serum β_1A globulin content contribute to the diagnosis of these disorders and differential diagnosis, and can be used to evaluate the efficacy. Second, 25 patients with chronic nephritis serum β 1 A globulin levels decreased only 2 cases. The mechanism of its decline is still under study. Morphological observation