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毛细支气管炎是婴幼儿常见的下呼吸道感染性疾病,病毒感染是主要致病原因。毛细支气管炎的病理、生理变化与哮喘有许多相同之处,许多炎性介质参与其中,造成呼吸道高反应,诱发喘息。在这些炎性介质中,白三烯在毛细支气管炎呼吸道炎症的发生中起到重要作用,而白三烯受体拮抗剂在毛细支气管炎的治疗中取得较好疗效。现就白三烯受体拮抗剂的作用机制及其在毛细支气管炎中的临床研究进行综述,探讨毛细支气管炎的治疗及早期干预以及降低喘息复发率的有效方法。
Bronchiolitis is a common lower respiratory tract infection in infants and young children, and viral infections are the major causative agents. Bronchiolitis pathology, physical changes and asthma have many similarities, many inflammatory mediators involved, resulting in respiratory tract hyperresponsiveness, induced wheezing. Among these inflammatory mediators, leukotrienes play an important role in the pathogenesis of bronchiolitis and airway inflammation, and leukotriene receptor antagonists have a good effect in the treatment of bronchiolitis. Now leukotriene receptor antagonist mechanism of action and its clinical research in bronchiolitis are reviewed to explore the treatment of bronchiolitis and early intervention and reduce the recurrence rate of respite effective method.