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朊蛋白疾病是一组致死性的神经变性病,但目前在早期诊断、监测患者的病情变化等方面尚缺乏明确特异性的生物学标志物。发现可靠的生物学标志物对朊蛋白疾病的早期诊断和预防具有重要意义,与之相关的研究在国内外已取得了长足进步。本文综述了近年来1 4-3-3蛋白、β淀粉样蛋白、Tau蛋白、S1 0 0蛋白以及神经元特异性烯醇化酶(NSE)、脑型肌酸激酶和脂肪酸结合蛋白等生物学标志物在疾病诊断、临床表现及病情进展等相关方面的研究进展。
Prion diseases are a group of fatal neurodegenerative diseases. However, there are currently no specific biological markers for early diagnosis and monitoring of patient’s condition. The discovery of reliable biomarkers is of great importance for the early diagnosis and prevention of prion diseases, and the related research has made great strides at home and abroad. This review summarizes the recent progress in the biomarkers of 1 4-3-3, β-amyloid, Tau, S100 and neuron-specific enolase (NSE), brain-type creatine kinase and fatty acid binding protein In the diagnosis of disease, clinical manifestations and progression of the disease and other related aspects of research progress.