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目的观察18α甘草酸(18α-GA)对D-氨基半乳糖(GalN)引起大鼠急性肝损伤的治疗作用。方法 SD大鼠60只,随机分为6组,除阴性对照组外,所有动物同时腹腔注射10%GalN溶液500 mg/kg,给药组于GalN处理前3 d分别腹腔注射18α-GA 15、30、60 mg/kg,每日一次,GalN处理30 h后取血测定血清ALT、AST,并取肝左叶作病理组织学观察。结果 18α-GA能明显抑制急性肝损伤大鼠血清转氨酶的活力,并减轻肝脏病理损伤。结论 18α-GA对GalN引起大鼠急性肝损伤具有防治效果。
Objective To observe the therapeutic effect of 18α-GA on acute hepatic injury induced by GalN in rats. Methods Sixty Sprague-Dawley rats were randomly divided into 6 groups. All animals except for the negative control group were injected intraperitoneally with 500 mg / kg 10% GalN solution. The rats in the treatment group were intraperitoneally injected with 18α-GA 15 three days prior to GalN treatment, 30, 60 mg / kg, once daily, serum GalN for 30 h and then serum for determination of ALT, AST, and take the left lobe of liver for histopathological observation. Results 18α-GA can significantly inhibit the activity of serum aminotransferase in acute liver injury rats, and reduce the pathological damage of liver. Conclusion 18α-GA can prevent and treat acute liver injury induced by GalN in rats.