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目的:评价血管内皮生长因子(VEGF)基因的多态位点与不明原因复发性自然流产发生风险的相关性。方法:检索Pubmed数据库、Medline数据库、Cochrane图书馆数据库、中国知网(CNKI)、维普中文科技期刊数据库、万方数据库、中国生物医学文献数据库中有关VEGF基因多态性与不明原因复发性自然流产的病例-对照研究,对纳入的研究进行质量评价,采用Rev Man5.3软件进行数据分析。结果:最终纳入11篇文献对VEGF基因的-634G/C(rs2010963)、+936C/T(rs3025039)、-2578C/A(rs699947)及-1154G/A(rs1570360)4个位点进行评价,累计病例组1945例,对照组2074例。Meta分析结果显示,在VEGF基因的-634G/C位点,基因型CC发生复发性自然流产的风险高于基因型GG[P=0.03,OR=1.29,95%CI(1.03,1.63)];携带等位基因C妇女的发病风险高于携带等位基因G[P=0.02,OR=1.14,95%CI(1.02,1.27)]。+936C/T位点的CT、TT基因型及携带T等位基因发生复发性自然流产的风险高于CC基因型及携带C等位基因的女性[CT vs CC基因型:P<0.0001,OR=1.40,95%CI(1.18,1.65),TT vs CC基因型:P=0.02,OR=1.72,95%CI(1.11,2.66),T vs C等位基因:P<0.00001,OR=1.52,95%CI(1.30,1.78)];两组的-1154G/A、-2578C/A各基因型比较,差异均无统计学意义(P>0.05)。结论:VEGF基因-634G/C(rs2010963)、+936C/T(rs3025039)位点的单核苷酸多态性与不明原因的复发性流产发生可能相关。
Objective: To evaluate the relationship between the polymorphism of vascular endothelial growth factor (VEGF) gene and the risk of unexplained recurrent spontaneous abortion. Methods: We searched the Pubmed database, Medline database, Cochrane Library Database, CNKI, VIP Chinese Science and Technology Periodical Database, Wanfang database, China Biomedical Literature Database for the relationship between VEGF gene polymorphism and unexplained recurrent spontaneous abortion Case-control study, the quality of the included studies was evaluated, and data analysis was performed using Rev Man 5.3 software. Results: In the end, 11 articles were included in the evaluation of the four sites of -634G / C (rs2010963), +936C / T (rs3025039), -2578C / A (rs699947) and -1154G / A (rs1570360) 1945 cases of cases, 2074 cases of control group. Meta - analysis showed that genotype CC had a higher risk of recurrent spontaneous abortion than genotype GG at -634G / C of VEGF gene (P = 0.03, OR = 1.29, 95% CI (1.03,1.63)]; Women with allele C had a higher risk of developing disease than those with allele G [P = 0.02, OR = 1.14, 95% CI (1.02, 1.27)]. CT and TT genotypes at + 936C / T locus and women with recurrent spontaneous abortion with T allele were higher than those with CC genotype and C allele [CT vs CC genotype: P <0.0001, OR = 1.40, 95% CI (1.18, 1.65), TT vs CC genotype: P = 0.02, OR = 1.72, 95% CI 95% CI (1.30,1.78)]. There was no significant difference in the -1154G / A and -2578C / A genotypes between the two groups (P> 0.05). CONCLUSIONS: The single nucleotide polymorphisms of VEGF gene -634G / C (rs2010963) and + 936C / T (rs3025039) may be associated with unexplained recurrent spontaneous abortion.