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以环酮和季戊四醇为原料,磷钨酸为催化剂,在甲苯中回流分水反应合成了系列氧杂三螺环化合物(3a~3h),其中5,9,14,17-四氧杂三螺[3.2.2.3~(10).2~7.2~4]十七烷(3a)和7,11,18,21-四氧杂-3,15-二硫杂三螺[5.2.2.5~(12).2~9.2~6]二十一烷(3f)为新化合物,其结构经~1H NMR,~(13)C NMR和HR-MS(ESI)表征。并以3c的合成为模板反应,对反应条件进行了优化。
A series of oxa-trispiro-ring compounds (3a ~ 3h) were synthesized from cyclic ketone and pentaerythritol as raw materials and phosphotungstic acid as catalyst in refluxing toluene. Among them, 5,9,14,17-tetraoxaspiro [3.2.2.3 ~ (10) .2 ~ 7.2 ~ 4] Heptadecane (3a) and 7,11,18,21-tetraoxa-3,15-dithiatrispiro [5.2.2.5 ~ (12 ) 2 ~ 9.2 ~ 6] heneicosane (3f) is a new compound whose structure has been characterized by ~ 1H NMR, ~ 13 C NMR and HR-MS (ESI). The synthesis of 3c was used as the template reaction to optimize the reaction conditions.