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17-1A is a tumor associated antigen.Monoclonal antibody (mAb) against 17-1A has been used in adjuvant therapy of colorectal carcinoma.Using mAb against 17-1A antigen on affinity chromatography, a novel putative tumor associated antigen (P50) whose relative molecular mass is 5.0×104 has been isolated from human colorectal tumor tissues which are recognized by mAbs 17-1A and M79, while the relative molecular mass of 17-1A antigen isolated from several colorectal tumor cell lines is 3.3×104.P50 was recognized by mAbs 17-1A and M79 which are specific mAbs against 17-1A antigen.