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美沙酮主要用于镇痛和治疗海洛因依赖脱毒、替代维持治疗。吸毒成瘾者是HIV病毒感染的高危人群。对于接受美沙酮维持治疗的HIV阳性携带者,了解、熟悉美沙酮与抗逆转录病毒药物的相互作用是非常重要的。二者的相互作用有可能导致戒断症状的出现或者美沙酮相对过量。本文主要论述药物治疗阿片类药物依赖和AIDS时,美沙酮与抗逆转录病毒药物已报道或有可能发生的相互作用。
Methadone is mainly used for analgesic and heroin dependence detoxification, alternative maintenance therapy. Addicts are at high risk for HIV infection. For HIV-positive carriers who receive methadone maintenance treatment, it is important to understand and be familiar with the interaction of methadone with antiretroviral drugs. Interaction between the two may lead to the emergence of withdrawal symptoms or methadone relative overdose. This article focuses on the interactions that methadone and antiretroviral drugs have reported or are likely to cause when they are used to treat opioid dependence and AIDS.